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Genetic polymorphisms of the DNA repair gene UNG are associated with the susceptibility of rheumatoid arthritis

The involvement of uracil-DNA glycosylase (UNG) in the pathogenesis of cancer is well documented. In contrast, the role of this protein in rheumatoid arthritis (RA) development is not well defined, although previous studies suggest a possible link between autoimmune diseases and malignancy. Therefore, we aimed to examine whether there is a link between UNG genetic

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PPAR-gamma Pro12Ala and ACE I/D polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome

BACKGROUND Metabolic Syndrome (MetS) results from the combined effect of environmental and genetic factors. We investigated the possible association of peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) Pro12Ala and Angiotensin Converting Enzyme (ACE) I/D polymorphisms with MetS and interaction between these genetic variants. METHODS Three hundred sixty four unrelated Caucasian subjects were enrolled. Waist circumference, blood pressure, and

Cardiovascular disease: primary prevention, disease modulation and regenerative therapy

Cardiovascular primary prevention and regeneration programs are the contemporary frontiers in functional metabolic vascular medicine. This novel science perspective harnesses our inherent ability to modulate the interface between specialized gene receptors and bioavailable nutrients in what is labeled as the nutrient-gene interaction. By mimicking a natural process through the conveyance of highly absorbable receptor specific

Impact of diet on breast cancer risk: a review of experimental and observational studies

Breast cancer, which presents the highest global incidence of all female cancers, is caused by the interaction of genetic and environmental factors. Among the latter, diet has attracted considerable attention, as it is a modifiable risk factor and thus offers an opportunity to design preventive strategies. Nevertheless, only alcohol consumption has been unequivocally related to