Genetic polymorphisms of the DNA repair gene UNG are associated with the susceptibility of rheumatoid arthritis

The involvement of uracil-DNA glycosylase (UNG) in the pathogenesis of cancer is well documented. In contrast, the role of this protein in rheumatoid arthritis (RA) development is not well defined, although previous studies suggest a possible link between autoimmune diseases and malignancy. Therefore, we aimed to examine whether there is a link between UNG genetic

PPAR-gamma Pro12Ala and ACE I/D polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome

BACKGROUND Metabolic Syndrome (MetS) results from the combined effect of environmental and genetic factors. We investigated the possible association of peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) Pro12Ala and Angiotensin Converting Enzyme (ACE) I/D polymorphisms with MetS and interaction between these genetic variants. METHODS Three hundred sixty four unrelated Caucasian subjects were enrolled. Waist circumference, blood pressure, and