PPAR-gamma Pro12Ala and ACE I/D polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome

BACKGROUND Metabolic Syndrome (MetS) results from the combined effect of environmental and genetic factors. We investigated the possible association of peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) Pro12Ala and Angiotensin Converting Enzyme (ACE) I/D polymorphisms with MetS and interaction between these genetic variants. METHODS Three hundred sixty four unrelated Caucasian subjects were enrolled. Waist circumference, blood pressure, and